The cost of manufacturing a car is substantial and automobile manufacturers spend a significant amount of resources designing the appropriate line for the model of car they are trying to produce.

生产一辆汽车的成本非常可观，并且汽车制造商投入了大量的资源来为他们试图生产的汽车模型设计合适的生产线。

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Obesity is a significant public health problem in most developed countries and carries with it substantial morbidity and mortality.

在大多数发达国家，肥胖以及因其产生的高发病率和死亡率，是一个极受重视的社会要点问题。

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Searching for a long extent in a fragmented dbspace can take a significant amount of time since a dbspace may contain many small free extents that are searched over; this time can be substantial.

由于需要处理大量的空闲小区段，因此在数据库空间中查找长区段会耗费大量的时间；这种耗费是巨大的。

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Subs convey substantial benefits including significant experience and skill point boosts.

FORBES: The Secret World: Subscription Free, Time To Try?

G4S staff at Cedars centre near Gatwick used substantial force with significant risk to the unborn child, the Chief Inspector of Prisons said in a report.

BBC: G4S used force on pregnant woman at Cedars centre

Mr Sarris cited the "lack of substantial liquidity and significant risk of deposits outflow, with possible outcome the collapse of the credit institutions" as the reasons for the restrictions.

BBC: Cyprus banks to reopen on Thursday after bailout closure