Corporate response appears to have been substantial.

企业的反应似乎相当强烈。

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The creation of the message that represents the request and response and the transfer of this data across the network create substantial overhead.

创建表示请求和响应的消息，并跨网络传输这些数据会产生巨大的开销。

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The global response to the 2009 pandemic has provided a substantial amount of new experience and evidence in public health responses to influenza, its treatment and prevention.

2009年大流行的全球应对为流感的公共卫生应对、治疗和预防提供了大量新的经验和证据。

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He was given medicine intravenously to relieve the brain clot, and electric shocks were used to revive him but there was no substantial response.

CNN: Conflicting reports about whether Mubarak has died

Sir George did not assent to Tory MP Jesse Norman's response that "the very substantial opposition from within the Conservative party, not just that from Labour, was responsible for the withdrawal of the motion".

BBC: Ministers abandon planned timetable for Lords reform