However, there is the possibility of substantial variations across regions and even within countries.

然而，世界不同地区甚至各个国家内部可能存在巨大差异。

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Nuclear weapons are so destructive and ballistic missiles are so swift, that any substantial increased possibility of their use or any sudden change in their deployment may well be regarded as a definite threat to peace.

CENTERFORSECURITYPOLICY: Center For Security Policy

In conjunction with other circumstantial evidence, they have contributed substantial credence to the possibility of Tommy's guilt and, at the very least, suggest he has wilfully deceived authorities, with considerable success, for many years.

CNN: Moxley Case: Excerpts from the Sutton Report

Regeneron and Amgen, which is also developing a PCSK9 drugs, dismissed the possibility of a substantial delay.

FORBES: Analyst Is Skeptical Of Rival Company's Warnings About Regeneron