Objective To observe the effects of nifedipine on GRK2 expression in left ventricular hypertrophy myocytes and the subcellular distribution of GRK2 in spontaneous hypertensive rats，to explore the possible mechanism of nifedipine to improve the cardiac hypertrophy.
目的 观察硝苯地平对自发性高血压大鼠(SHR)左心室肥厚心肌细胞GRK2的表达及亚细胞分布的影响，探讨硝苯地平逆转心肌肥大的可能机制。
参考来源 - 硝苯地平对自发性高血压大鼠左心室肥厚心肌细胞蛋白偶联受体激酶的表达及亚细胞分布的影响In this study, several HER-2/neu antisense ODNs (HA-2741, 824, 193 and 1027) with different sequences were picked up to study the relationship between inhibitory effect and subcellular distribution in target cell SK-BR-3, which overexpress p185HER2/neu.
在本研究中,我们选取其中4条活性明显不同的序列:HA-2741、HA-824、HA-193和HA-1027,研究其对靶基因表达抑制的时相性变化和在p185HER2/neu高表达靶细胞株SK-BR-3内微观分布的时相性变化的相关性。
参考来源 - HER·2,447,543篇论文数据，部分数据来源于NoteExpress
In all those samples, there were no alterations in the subcellular distribution of cytochrome oxidase, a mitochondrial respiratory chain protein.
在所有样品中， 线粒体呼吸链蛋白细胞色素氧化酶没有变化， 表明线粒体的制备方法是可靠的。
The subcellular distribution, gene expression, and inherent activity of GLUT4 directly affect the glucose transmembrane transportation induced by insulin.
GLUT4的亚细胞分布、 基因表达量以及功能活性，都将直接降影响胰岛素作用下葡萄糖的跨膜转运。
Conclusion Altered subcellular distribution of DNR in resistant cell line was related to MDR gene formation. Quercetin could inhibit MRP1 function and could restore the subcellular DNR distribution.
结论DNR在耐药细胞中的异常分布与肿瘤细胞耐药基因形成有关，槲皮素在体外直接抑制MRP1功能，恢复DNR在细胞内的分布。
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