A novel ion exchanger prepared from a strong anion resin modified with histidine was used for purifying crude hyaluronic acid to achieve a successful separation from protein and nucleic acids.

以含有多个氮原子的组氨酸对强碱型阴离子树脂进行修饰，获得一种新型的离子交换剂。用该离子交换剂对透明质酸粗品进行离子交换层析，使透明质酸与蛋白质、核酸达到有效的分离。

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