In one study of 1, 740 men with high cholesterol, Scottish researchers found that men with high levels of the Lp-PLA2 enzyme had twice the risk of heart attacks, an effect that was statisticallyindependent of their cholesterol levels.
In May 2007, my colleague Kathy Wolski and I published an independent analysis of Avandia in the New England Journal of Medicine (NEJM), showing a statistically significant 43% increase in heart attack.