Any mutation in the porypyrimidine (py) tract and the branch point consensus sequence of introns that affected splicing did so by interfering with efficient spliceosome assembly and splicing of pre - mRNAs.
内含子的嘧啶富集区the polypyrimidine(py)tract和支点一致序列(the branch point consensus sequence)中的任何突变都将通过干扰剪接体组装效率和mRNA前体(premRNA)的剪接直接影响剪接过程。
参考来源 - 喉癌p53基因突变和STK15基因过表达与中心体异常相关性研究·2,447,543篇论文数据,部分数据来源于NoteExpress
以上来源于: WordNet
Spliceosome assembly occurs co-transcriptionally, raising the possibility that DNA structure may directly influence alternative splicing.
剪接体组装与转录同步进行,提示DNA结构可能直接影响可变剪接。
RNA splicing is carried out by the spliceosome, which is a large, dynamic complex composed of more than a hundred proteins and several small nuclear RNAs.
RNA剪接是由一个上百个蛋白质和数条小核r NA组成的复杂的动态复合体完成的。
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