The spiramycin producing strain Streptomyces spiramyceticus XCH1-23 was treated with UV irradiation. The 2-deoxy-D-glucose tolerant mutants, valine tolerant mutants, soybean oil tolerant mutants and SPM resistant mutants were screened by means of rational selection and natural selection, respectively.
以螺旋霉素链霉菌XCH1-23为出发菌株，通过紫外线诱变处理，结合理性选育和自然分离，筛选得到耐2-去氧葡萄糖、缬氨酸和耐豆油突变株，在此基础上，筛选得到抗自身产物的突变株。
参考来源 - 螺旋霉素高产菌种选育及发酵工艺优化·2,447,543篇论文数据，部分数据来源于NoteExpress
Some technological conditions for the separation of spiramycin, using amyl acetate impregnated resin, were studied.
本文首次研究了醋酸戊酯浸渍树脂吸附分离螺旋霉素的工艺条件。
Conclusion Acetyl spiramycin shows significant efficacy on chronic urticaria patients with positive serum toxoplasma.
结论血清弓形虫抗体阳性的慢性荨麻疹患者使用乙酰螺旋霉素治疗，疗效显著。
There are several impurities in the spiramycin fermentation broth which leads to a lower yield and lower quality of the product.
目前螺旋霉素生物合成的发酵杂质含量过高，导致成品收率过低，杂质含量不符合药典规定。
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