CONCLUSION: BMMSCs can promote the regeneration of neuron axon of spinal injury region after transplantation through up-regulating the expression of BDNF.
结论:骨髓间充质干细胞移植后可能通过上调脑源性神经营养因子的表达从而促进脊髓损伤区神经元轴突的再生。
Objective: to investigate the effects of the expression of exogenous brain derived neurotrophic factors (BDNF) on injured spinal cord following in vivo adenoviral gene transfer to the cord.
目的:研究腺病毒介导的脑源性神经营养因子(BDNF)基因在大鼠损伤脊髓内的表达规律,观察外源性BD NF对损伤脊髓的作用。
Therefore, BDNF may be involved in the normal physiological function and the plasticity of spinal cord after damage.
说明脑源性神经营养因子既参与脊髓的正常生理功能,也与其损伤后的可塑性有关。
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