The mother river is in great need of protection because something is wrong with it.

母亲河急需保护，因为它出了问题。

youdao

Something is wrong with my iPad, isn't it?

我的苹果平板电脑出毛病了，是吧？

youdao

Something is wrong with the machine.

那机器有点问题。

《新英汉大辞典》

But the laws have not kept up with the times. There is something wrong with that picture.

VOA: standard.2009.07.27

We don't give ourselves the permission to be human, because we think there is something wrong with us if we experience these emotions.

我们不准许自己为人，因为我们觉得是自己有毛病,如果我们有这样的情绪。

哈佛公开课 - 幸福课课程节选

To have a stereotype is to be-- is to have something wrong with you.

说你有刻板印象-,就是说你有问题。

耶鲁公开课 - 心理学导论课程节选

The first clue that something is wrong with Wall Street's next big thing is that it is Shariah-compliant.

CENTERFORSECURITYPOLICY: Into the fire

They would say something is wrong with it. yeah you cracked the screen.

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For example, wearable health monitors could be used to notify you or your doctor as soon as something is wrong with your vital signs.

CNN: CES keynote: Young people today are 'born mobile'