So if you really want class to make a difference in your life, it's up to you.

所以如果你真的想通过这门课改变生活，一切取决于你。

哈佛公开课 - 幸福课课程节选

So, she had a precursor. So what? Does that make any difference?

所以，在她之前有过别人，那有怎样，会造成不同吗？

耶鲁公开课 - 1945年后的美国小说课程节选

But whether or not you do so doesn't seem to make a big difference.

但不论你是否选择这样做,都不会有什么太大的影响

耶鲁公开课 - 心理学导论课程节选

Yet it is possible that those "protective" factors, once identified and understood, could play an important role in pointing toward new treatments and interventions that capitalize on those protective factors and so make a real difference to long-term outcomes.

CNN: How girls and boys differ when it comes to autism

So can a film really make a difference in how the public currently perceives Palin?

FORBES: Could a Feature Film Help Sarah Palin's Presidential Chances?

So these efforts make a difference.

WHITEHOUSE: Remarks by the First Lady at a Campaign Event -- La Jolla, CA