If you confront every single issue, your colleagues will start to associate you with discomfort.

如果一遇到问题，无论大小，你都跳出来，这会让你的同事很不舒服。

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Though David's manner is more cosmopolitan, and more genial, than that of Charles, Brian Doherty, who has interviewed both brothers, couldn't think of a single issue on which the brothers disagreed.

虽然戴维的行止较之查理斯更为公开，采访过兄弟二人的布莱恩·多尔蒂没发现兄弟二人产生过分歧。

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Mark Pack, co-editor of the Liberal Democrat Voice website, said: "Party members will understand the underlying point Nick Clegg was making - that this isn't a single-issue coalition."

马克·派克是自民党之声的编辑，他说：“党内成员会明白尼克·克莱格想要强调的潜在观点——这不是一个单一问题的联合。”

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Health care is an enormous issue. It affects every single one of us and we want to get it right,"

VOA: standard.2009.08.12

We can already use that in terms of single ions to think about a really complex biological issue, which is to talk about ion channels.

我们已经能够仅仅凭借这个关于单个离子的原理,来讨论一个非常复杂的生物问题了，我们要讨论的就是离子通道。

麻省理工公开课 - 化学原理课程节选

It was by far the most feedback on any single issue in the programme's history.

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And people here clearly understand there's more at stake than a single issue like that.

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And maybe - just maybe - you don't agree with this party on every single issue.

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