The Cottagers took 21 seconds to make amends for Wolfsburg's late goal in the first leg as Bobby Zamora neatly turned Jan Simunek and slotted his side ahead.
The goal, which saw him collect Zoltan Gera's pass, turn Jan Simunek and slot home, was Zamora's sixth in Europe this year and his 19th in total in what has been an excellent season for the striker.