A broad range of alcohol consumption patterns, from occasional hazardous drinking to daily heavy drinking, creates significant public health and safety problems in nearly all countries.

从偶尔有害饮酒到每日大量饮酒等一系列酒精消费模式在几乎所有国家都造成严重的公共卫生和安全问题。

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Stability analysis and selection of safety coefficient are significant technical problems.

稳定性分析和安全系数选取是防治的重要技术问题。

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Putting aside the lost revenues to Tre Milano, counterfeit versions of the InStyler can create other problems: they pose significant safety hazards to consumers, and unwitting buyers of the defective or poorly constructed counterfeit items are unfairly panning InStyler in consumer reviews.

FORBES: Amazon.com's Anti-Counterfeiting Efforts Blessed by California Appellate Court

Wayne Bartlett, the project's regional director, said there were "significant" problems and the service had been been withdrawn in Worcestershire to "ensure patient safety was not compromised".

BBC: Worcestershire withdraws NHS 111 advice line