Keep in mind that this can have significant negative performance implications.

请记住，这对性能有显著的消极影响。

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Poor database storage design can have a significant negative impact on a database server.

糟糕的数据库存储设计对数据库服务器有极大的负面影响。

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Overall, the percentage who reported at least one significant negative life event increased from 88% to 92%.

从整体上看，说自己至少有一件重大消极事件的人数比例从88%上升到了92%。

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This is likely to have a significant negative impact on its year-over-year and sequential revenue figures.

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But as mining slows, it could have a significant negative impact on the Australian economy, Eliseo said.

FORBES: INTERVIEW: Cut In Australian Interest Rates May Push Aussies Toward Gold --Economist

Its last reading was a significant negative surprise, showing a decline from 68.0 in February to 59.7 in March.

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