Can the HMGB1-CD24-Siglec system limit the more severe forms of sterile inflammation, such as sepsis?

HMGB1 - CD 24 - Siglec系统能限制更严重的无菌性炎症反应，如脓毒症吗？

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In fact, HMGB1 was found to directly associate with CD24 and Siglec-G, a member of the sialic acid-binding immunoglobulin-like lectin family.

实际上，HMGB1被发现与CD 24和Siglec - g，唾液酸结合性免疫球蛋白样凝集素家族中的一员直接相关。

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CD24 does not contain a cytosolic domain, and signals through Siglec-G, which contains an immune receptor tyrosine-based inhibitory motif (ITIM).

CD 24并不具有胞质内结构域，但通过Siglec - g传递的信号就包括了一个免疫受体酪氨酸相关抑制性基序immune receptor tyrosine - based inhibitory motif (ITIM)。

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