With the removal of oxygen from sickle hemoglobin, the red blood cell deforms into a sickled shape. This sickling damages the RBC membrane and increases the likelihood of rupture and anemia.

随着镰珠蛋白中氧的去除，红细胞变形成镰状，红细胞膜受到破坏，破裂的可能性增加，从而导致贫血。

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Persons with sickle cell trait (Hemoglobin AS) are much less likely to have this happen.

带有镰状细胞特性(血红蛋白as)的人并不常发生这种情况。

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Sickle cell disease is a disorder in which blood cells carry a mutation in hemoglobin.

镰状细胞贫血病是由于血细胞携带了一种突变的血红蛋白导致的紊乱。

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Here's the difference between normal hemoglobin and sickle hemoglobin, I can make - I can see a chemical difference, I can exploit it, how can I find it?

正常血红蛋白和镰状红细胞贫血的,血红蛋白有不同之处,我能够--我能看出有化学差异,我能去探寻差异,那么我怎么找到它呢

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It's on the gene for hemoglobin and the hemoglobin that you produce if you have sickle cell anemia is not quite right because there's one base difference.

这个缺陷基因和血红蛋白有关,如果你有镰状红细胞贫血症,那你所产生的血红蛋白就不太正常,因为这里有一个碱基不同

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In a normal cell DNA that DNA in the normal cell - this DNA gets cut by the restriction enzyme, so the sickle gene ends up - so that hemoglobin gene ends up in two pieces.

一个正常细胞的DNA,正常细胞里的DNA,会被限制酶所剪切,因此镰状血红蛋白基因--,不对,是正常血红蛋白基因被切成两段

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There are several common hemoglobin disorders such as sickle cell trait and the thalassemias that are generally asymptomatic and generally of no consequence to the patient having it, but patients can have erroneous HgA1C measurements.

CNN: Why do my A1C results from different sources vary?