Sickle cell nephropathy

• abstract: Sickle cell nephropathy is a type of nephropathy associated with sickle cell disease, it causes renal complications as a result of sickling of red blood cells in the microvasculature. The hypertonic and relatively hypoxic environment of the renal medulla, coupled with the slow blood flow in the vasa recta, favors sickling of red blood cells, with resultant local infarction (papillary necrosis).

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