His story shows that nobody, however bad their situation is, should lose hope.

他的故事告诉我们，无论处境多么糟糕，任何人都不应该失去希望。

youdao

He strongly believes that his story shows that nobody, how bad their situation is, should lose hope.

他深信他的故事表明，没人，他们是多么糟糕的局面，应该失去希望。

youdao

We must accept finite disappointment, but we should never lose infinite hope.

我们必须接受有限的失望，但我们也应当从不丧失无限的希望。

youdao

This is not to say advocates should lose hope on tax reform.

FORBES: A Modest Proposal For Tax Reform: Make The IRS Pay Us For Filing A Return

All of these are challenges to journalism, but we should not lose hope in the potential of the Internet to provide high-quality news.

CNN: Commentary: News can outlast newspapers