Even active, upbeat people (of any age) can get depressed, and especially if there's a biological cause, you can't just shake out of it.

即便是积极乐观的人(任何年龄段)也可能感到抑郁，特别是有生理上原因的时候，你不可能简单的摇摇头然后就走出来了。

youdao

She bent down to shake a pebble out of her shoe.

她弯下腰，把鞋里的一粒石子抖出来。

《牛津词典》

This should be the year of a big shake-out in Italian banking.

这应该是意大利银行业大规模重组的一年。

《柯林斯英汉双解大词典》

When the young man stepped in front of McKinley, McKinley reached out to shake his hand.

VOA: special.2010.07.29

This boost could outweigh the much-touted negative effect of a shake-out of labour as companies restructure and, in any case, that shake-out might not happen to any great extent if the economy as a whole is recovering, taking incomes and profits up with it.

ECONOMIST: Just possibly, something to sing about at last | The

But it is part of a global roll out, one that should shake Apple out of its complacency in retail.

FORBES: Samsung Resets The Smartphone Landscape with Best Buy Deal

Mexico suffered a big shake-out of its industry when NAFTA came into effect in 1994.

ECONOMIST: Brazil, Mexico and trade