CONCLUSION: 0.75 % metronidazole gel is both effective and safe in the treatment of moderate to severe rosacea.

结论：0 . 75 %甲硝唑凝胶治疗中、重度酒渣鼻的疗效肯定，安全性高。

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AIM: to evaluate the efficacy and safety of 0.75 % metronidazole gel in the treatment of moderate to severe rosacea.

目的：评价0 . 75 %甲硝唑凝胶治疗中、重度酒渣鼻的临床疗效和安全性。

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BACKGROUND: Systemic isotretinoin has been known for decades to be effective in the treatment of severe forms of rosacea, but it must be used off-label because of the lack of evidence-based data.

背景：全身性异维a酸有效的治疗重症红斑痤疮已有几十年了，但是由于缺乏基于证据的数据，故其作为非适应证使用。

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