Severe changes in energy and behavior go along with these changes in mood.

精力和行为的剧烈改变常伴随着心境上的改变。

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We also face the specter of nonlinear "tipping points" that may cause much more severe changes.

我们还面临另一个幽灵，那就是非线性的“气候引爆点”，这会带来许多严重得多的变化。

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We also face the specter of non-linear "tipping points" that may cause much more severe changes.

我们还会面临另一个妖魔-导致更严重变化的非线性的“临界点”。

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The seeds and pollen, or the lack of them, can show severe weather changes over thousands of years.

VOA: special.2010.04.07

Any marginal changes in the weather,she says, can drive thousands of children into a situation of severe and acute malnutrition.

VOA: standard.2010.02.04

The problem is that just as price changes have to be severe to manifest any impacts on gas consumption, price changes on their own also tend not to do much to inspire the development of radical new tech solutions, unless prices are through the roof.

FORBES: Raising Gas Taxes Wouldn't Cut Consumption, But It Still Makes Sense

The consequences of these changes are severe and have had a significant negative impact on private companies and their investors.

FORBES: The Case For Private Company Stock Marketplaces

To get to your question, the antidepressant potential of ketamine was discovered serendipitously in patients receiving the drug for the treatment of complex regional pain syndrome, or CRPS, a miserable condition characterized by severe pain, swelling and changes in the skin.

CNN: Is it safe to use ketamine as a pain drug?