Many (just like younger people with serious illness and disabilities) desperately need practical guidance from their doctors as to what is possible for them.

许多人(就像患严重疾病或残障的年轻人一样)严重需要他们的医生在可行的方面给予他们实际的指导。

youdao

It's a serious suggestion in that I believe it is the most promising and practical option in terms of current technology to solve the biggest parts of the problem.

这是一个严肃的建议，因为我相信在目前的技术条件下，它能解决气候变暖的大部分问题，因而最有前途的和最可行的选择。

youdao

The law, a relic of the Cold War, has no practical effect but is a serious irritant in relations between the two countries.

该法令是冷战的产物，虽已没有任何实际作用，却是影响两国关系的一个刺激物。

youdao

It is arguably the first serious practical attempt to deal with the various problems America faces.

ECONOMIST: Energy policy and the environment

But there are quite serious practical arguments about that which are difficult.

BBC: Breakfast with Frost

You can be as serious or as snarky, as witty or as practical, as staid or as droll (you get the idea) as you want to be.

FORBES: Redesign the IRS Web Site