Very funny, but it doesn't make any sense to me.

很有趣，但是它对我来说没有任何意义。

youdao

A sense of desolation overwhelmed me.

我感到无限凄凉。

《新英汉大辞典》

While the news at first shocked me, on reflection it made perfect sense.

虽然一开始这个消息令我震惊，但经过认真思考，觉得它也很有道理。

《柯林斯英汉双解大词典》

And any argument between us would not cause me to lose heart or feel a sense of loss.

VOA: special.2010.07.11

And when you can write that down, for me, there is just tremendous sense of creativity and of purpose and meaning.

当你能把它写出来的时候，对我个人来说，会感到这种来自巨大的创造性,目的性，意义性的满足感。

普林斯顿公开课 - 人性课程节选

What I saw in her, what she gave to me, a strong sense of faith, of confidence and trust in God.

她所给予我的，我从她身上看到的，是对上帝的绝对信仰。

普林斯顿公开课 - 人性课程节选

In fact, this summer, I slipped for the first time and hit my head on the rocks, either knocking some sense into me, or knocking what little sense I had left right out (it depends upon whom you ask).

FORBES: The Fall 2012 Sports Gear Guide

Most grown people will not come out and ask me about my condition, so in order to make sense of me they have to either watch and gather information through observation or use their own preconceived notions.

CNN: January 26, 2013 -- Updated 1642 GMT (0042 HKT)

My colleagues helped, explaining all sorts of technical tasks that made no sense to me.

CNN: We dare you to take a real vacation