...主,且感染的神经元可长时间存活; 2.在HCMV 感染的NPC模型的基础上,进一步发现HCMV感染可导致NPC 丧失自我更新的能力(self-renew)和多分化潜能;3.在HCMV感染诱导NPC增殖分化异常机制上有新的突破。
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概念:癌症干细胞是指具有转移或种植潜能的癌细胞,具有“自我年轻化(self-renew)”的特征,可形成表型相似的成瘤癌细胞,也可形成增殖潜能有限的表型多样化癌细胞。
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self renew 自我更新
Proliferation and self-renew abilities were similar or surpass that in bone marrow.
并且脐带血中的造血干细胞的增殖能力与自我更新能力超过或相似于骨髓中的造血干细胞。
参考来源 - 体外诱导人脐带血干细胞向肝细胞样细胞分化的研究Embryonic stem cells(ESCs)can self-renew and proliferate indefinitely in vitro,which retain their capability to differentiate into all cell types.
胚胎干细胞(embryonic stem cells,ESCs)是具有自我更新和高度分化潜能的细胞,能在体外保持未分化状态无限增殖传代。
参考来源 - 昆明小鼠胚胎干细胞建系的初步研究·2,447,543篇论文数据,部分数据来源于NoteExpress
These cells are termed cancer stem cells because, like normal stem cells, they possess the ability to self-renew and make differentiated progeny.
它们之所以像正常干细胞一样被冠以此名,是因为它们具有自我更新和形成分化子代的能力。
Neural stem cells have the potential to differentiate into neurons, astrocytes, and oligodendrocytes and to self-renew sufficiently to provide the Numbers of cells in the brain.
神经干细胞具有分化成神经元、少突胶质和星形胶质细胞的功能且能不断自我增殖。
Cancer stem cells, a small subset of cells found in solid tumors, have the capacity to self-renew and differentiate, initiate tumors and drive tumor growth, recurrence and metastasis.
肿瘤干细胞是在实体肿瘤中发现的一个小的细胞亚群,其具有自我更新和分化、引发肿瘤并促进肿瘤生长、复发和转移的能力。
This pluripotent stem cell is able to self-renew and it's able - generating committed progenitors of either the myeloid or the lymphoid lineage.
这种多能干细胞能自我更新,也可以生成定向祖细胞,可以是髓系祖细胞或者淋巴祖细胞
It could be those differences that they experience in their extracellular environment that lead to their choice to either self-renew or to become committed.
有可能就是由于,这种细胞外环境的不同,最终导致它们自我更新,或者成为定向的祖细胞
They might self-renew they might not, they have much more limited potential than before.
它们也许能自我更新,也许不能,它们比之前的干细胞潜能更少
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