马查多-约瑟夫病(MJD)/脊髓小脑共济失调3型(SCA3),是由MJD1基因编码产物ataxin-3的C-末端的编码谷氨酰胺的密码子CAG发生重复扩展突变而引起的一种常染色体显性遗传的多聚谷氨酰胺...
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遗传性III-型脊髓小脑型共济失调症(Spinocerebellar Ataxia 3，SCA3)是一种神经退行性疾病，与其相关的基因ataxin-3上CAG重复序列发生突变，编码多聚谷氨酰胺（Po...
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遗传性III-型脊髓小脑型共济失调症(Spinocerebellar Ataxia 3，SCA3)是一种神经退行性疾病，与其相关的基因ataxin-3上CAG重复序列发生突变，编码多聚谷氨酰胺（Po...
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Objective to study the role of cell apoptosis in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).
目的研究细胞凋亡在脊髓小脑性共济失调3型(SCA3)分子发病机制中的作用。
Objective To analyze the role and location of ubiquitin-dependent proteolysis pathway (UPP) in PC12 cells transfected by plasmids with spinocerebellar ataxia type 3 (SCA3) gene.
目的分析泛素依赖的蛋白水解通路(UPP)在转染了脊髓小脑性共济失调3型(SCA3)基因的PC 12细胞中的定位及作用。
Methods The length of genetic segment of SCA1, SCA2 and SCA3 in 92 patients with ataxia of unknown origin were detected by polymerase chain reaction (PCR) and agarose gel electrophoresis.
方法应用PCR方法和琼脂糖凝胶电泳对92例不明原因共济失调先证患者测定其SCA1、SCA2和SCA3基因片段长度。
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