AIM: To investigate the effects of rolipram on the ability of learningandmemory and the activityofPDE4in hippocampus following the focalbraininjury induced by ischemia-reperfusionin rats.
In 1998 Kandel's team injected aging mice with a failed antidepressant called Rolipram, which prevents the breakdown of cyclic-AMP by blocking an enzyme called phosphodiesterase-4.