abstract:The restriction modification system (RM system) is used by bacteria, and perhaps other prokaryotic organisms to protect themselves from foreign DNA, such as the one borne by bacteriophages. This phenomenon was first noticed in the 1950s.
DNAmodification with restriction-modificationsystem is a component ofmicrobialimmunesystem, and DNA modificationwithout restrictionsysteminfluencesphenotypesbygeneregulation.