Objective Previous studies have demonstrated that LRP16 is an estrogen-responsive gene, its expression level is closely related with proliferation and invasive growth of human breast cancer cells.

目的既往研究表明LRP16基因是一个雌激素反应基因，其表达水平与乳腺癌细胞增殖及侵袭密切相关。

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Breast cancer can be broadly separated into hormone-responsive (ER-positive) and non-hormone-responsive (ER-negative) subtypes.

乳腺癌可以大致被分类为雌激素受体阳性与雌激素受体阴性两类。

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Other treatments include hormone therapy if the cancer is responsive to estrogen.

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The FDA approved the new treatment for about 20 percent of breast cancer patients with a form of the disease that is typically more aggressive and less responsive to hormone therapy.

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