Unfolded proteins accumulate during ER stress and ER resident proteins GRP78 and GRP94 protect cells against ER dysfunction.
内质网受压时未折叠蛋白积累,内质网驻留蛋白GRP78和GRP94保护细胞免于内质网功能异常。
The immune constitution of liver is quite distinct from other tissue or organs, containing a large proportion of resident innate immune cells such as macrophages, NK cells and NKT cells.
肝脏免疫系统的组成不同于其他组织,它包含了众多的固有天然免疫细胞,如巨噬细胞、NK细胞和NKT细胞。
Normal cells respond to ER stress by increasing transcription of genes encoding ER-resident molecular chaperones such as GRP94, GRP78 and PDI to facilitate protein folding.
细胞对这种应激的反应是增加一系列内质网分子伴侣如GRP94、GRP78和PDI等的表达。
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