因此,通过DNA损伤产生突变以及基因组复制(replication of genome)过程误差率增高皆为遗传毒性的表现。遗传毒性可分为DNA损伤、基因突变、染色体结构改变和染色体数目改变四类。
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Origin of genome replication 基因组复制起始区
The research on the pathogenesis of these viruses always focuses on the molecular mechanism of replication of genome.
对其基因组复制的分子机制的研究一直是此类病毒致病机制研究的重点。
Mutations can be induced by radiation, chemical treatment, foreign pathogens (e.g. viruses), or due to errors that occur during replication of the genome each time a cell divides.
突变可以是由辐射、化学作用、外部病原体(如:病毒)或细胞分裂时基因组复制错误造成。
He added that if the DNA on multiple mitochondrial chromosomes is replicating in concert, replication of the entire mitochondrial genome would occur faster.
他补充说,如果多线粒体染色体上的DNA同时复制,那么复制整个线粒体基因组将更快。
Certain segments of DNA are being converted into RNA, and whereas in replication, you have to copy the whole genome, the whole - all of the chromosomes, all of the DNA contained in the chromosomes of the cell in order to completely replicate it; transcription only works on particular sequences of DNA.
特定的DNA序列被转录为RNA,在复制的过程中,整条染色体都被复制,包括其中的全部DNA序列,都被分毫不差地复制下来,以保证复制的完整性,而转录过程只发生在特定的DNA序列上
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