The researchers built on fundamental discoveries on the structure and replication of DNA made by Nobel laureates James Watson, Francis Crick and Arthur Kornberg.

研究人员希望继诺贝尔奖获得者詹姆士。华特森，弗朗西斯。科里克，亚瑟。科恩伯格之后在DNA的结构和复制领域有所重大发现。

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Antisense RNA exists in all kinds of living beings wildly. It ACTS on the course of the replication of DNA, transcription and translation, which realize the regulation and control of gene expression.

反义rna广泛存在于各类生物中，它作用于DNA的复制、转录、转译的过程，实现对基因表达的调控。

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Szostak said: "When we started the work, we were really just interested in the very basic question about DNA replication, how the ends of chromosomes are maintained."

绍斯塔克说：“当我们着手这项研究时，我们真的只是对有关DNA复制的基本原理及如何维护染色体末端感兴趣。”

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The result of this process if this replication went down the whole length of the DNA would be to form two identical, double stranded DNA molecules.

如果复制过程在整条链上持续进行的话,将生成两条完全一样的,双链DNA分子

耶鲁公开课 - 生物医学工程探索课程节选

The polymerase starts a process of replication of your DNA sequences.

聚合酶使DNA序列开始复制

耶鲁公开课 - 生物医学工程探索课程节选

Remember we talked about how DNA replicates itself and that there are enzymes, DNA polymerase that bind to the double stranded DNA, separate it, denature it locally, and then start the process of replication.

请记住DNA复制必须有酶的参与,DNA聚合酶结合在双链DNA上,打开双链并原位变性,然后才开始复制

耶鲁公开课 - 生物医学工程探索课程节选

Before the structure of DNA was unscrambled no-one had a clear idea how genetic replication - one of the cornerstones of life - worked.

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Cancers are driven to make copies of themselves, however, if cancerous cells run out of the building blocks of their DNA they develop "DNA replication stress".

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Prof Balasubramaninan said that was of key interest in the study of cancers, which were usually driven by genes, or oncogenes, that had mutated to increase DNA replication.

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