It's very difficult to give a reliable estimate.

要给出可靠的估计非常困难。

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In particular, for very large earthquakes moment magnitude gives the most reliable estimate of earthquake size.

尤其是对于特别重大的地震，“矩震级”能够确定出最为可信的地震规模。

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Currently the STAR team has a database of several dozen patients, but they estimate they will need a total of around 1, 000 before the software will be reliable.

目前，星团队已经获得几十名患者的数据，不过他们估计，还需要总共约一千人的数据，这款软件才能可靠。

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He says the Gail model provides a reliable estimate for the vast majority of women age 35 and older.

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