Objective: To optimize the preparation of miconazole nitrate malic acid-chitosan microsphere with uniform test design, the stability and release of microsphere were studied.
目的：以均匀设计法筛选优化硝酸咪康唑苹果酸化壳聚糖微球的制备工艺，提供可控性及预测性，并对微球稳定性和药物释放规律进行研究。
CONCLUSION The CCD-RSM can be applied to optimize the formulation of butoconazole nitrate sustained-release cream and the established model is of satisfactory predictive value.
结论星点设计-效应面法可用于硝酸布康唑缓释乳膏的处方优化，所建模型具有良好的预测能力。
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