For patients with refractory cases, treatment of the underlying systemic illness or surgery may be required.

对于病症顽固不缓解的患者，需对潜在的系统性疾病进行治疗或采取手术治疗。

youdao

CONCLUSION: Malignant glaucoma is refractory glaucoma with many pathogenetic factors, on which medication is effective in early period, while multiple surgery should be used in advanced stage.

结论：恶性青光眼是多种发病因素混合存在的难治性青光眼，早期药物治疗有效，后期多种联合手术则是最有效的方法。

youdao

The identification of brain regions generating seizures ('epileptogenic zone', EZ) in patients with refractory partial epilepsy is crucial prior to surgery.

术前对难治性部分性癫痫患者脑内癫痫发作的责任病灶（致癫区）的鉴定至关重要。

youdao

If someone has glaucoma - that is high pressure in the eyes - we can take care of that, if someone needs refractory surgery - that's surgery to correct focusing problems - we are able to provide that.

BBC: A Kenyan eye clinic with a long vision