So, it's out with the old 30-pin dock, but there's still optical, AUX, video out, RCA and 3.5mm jack connections if you prefer to keep things physically connected.
The back of the S4 is pretty much what you'd expect: a couple of spare sets of RCA stereo inputs, a mic input, TRS and RCA outputs, a MIDI passthrough, and a footswitch jack if you're into that sort of thing.