Hypoxia can directly induce pyruvate dehydrogenase kinase 1 (PDHK1) expression, which results in inactivation of PDH and the TCA cycle and subsequent suppression of metabolism (4).
低氧条件会直接诱导丙酮酸脱氢酶激酶1 (PDHK1)的表达，它的表达会抑制pdh的活性和TCA循环，从而抑制了随后的代谢通路(4)。
It plays a role in intermediary metabolism and energy production and may tightly associate or interact with the pyruvate dehydrogenase complex.
它在中间代谢和能源生产中起作用，并可能与丙酮酸脱氢酶复合体紧密联系或相互作用。
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