经验证明，对天然产物进行深刻系统的化学与生物学活性研究，对于发现临床上有用的原型药物(Prototype drug)存在极大的机遇；发现具有开发远景的结构新类型作为先导化合物(Leading compound)，对其结构进行润饰和优化以发现新药，更是一条...
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The clincher: Once a prototype drug works against one kinase, Vertex figures it can easily tweak the compound to inhibit other siblings in the kinase family--and then attack other protein groups, as well.
FORBES: Machine Gunner
By 1993 Inhale had a flashlight-size prototype, but most drug companies, wary after setbacks with nasal insulin, weren't interested.
FORBES: Waiting to Inhale
The prototype for targeted therapy is Roche's breast cancer drug Herceptin.
FORBES: American Society of Clinical Oncology
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