The invention provides a method for synthesizing (S)-N, N-dimethyl-3-hydroxyl-3-(2-thienyl) propylamine, and relates to a key intermediate of (S)-duloxetine.
N，N-二甲基-3-羟基-3-（2-噻吩基）丙胺的合成方法，涉及一种（S）-度洛西汀的关键中 间体。
From 1-phenyl-2-propylamine, selegiline hydrochloride, an anti-Parksins drug, was synthesized via N-methylation, enantiomer separation, N-alkylation and salt formation with an overall yield of 42.2%.
以1- 苯基- 2-丙胺为原料，经N- 甲基化、 拆分、N-炔基化、成盐共4步反应合成盐酸司来吉兰，总收率为42。
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