The expression on the creased, leathery face was one of profound sadness.

老头扭曲的皮革似的脸上浮现出一种深深的忧伤。

youdao

Those two lines of poetry express perfectly the profound sadness of loss.

这两行诗完美地表达了失去亲人的深切的悲痛。

youdao

The fact that one day God will end the world should lead the people of earth to experience a state of profound sadness and hopeless despair.

上帝有一天会毁灭世界的事实会把地上的人带入无尽的伤痛和灰心绝望中。

youdao

First Lady Michelle Obama is the great-great-granddaughter of African slaves "I think as Americans and African-Americans, obviously,there is a special sense that on the one hand this place was a place of profound sadness.

VOA: standard.2009.07.11

While president Jimmy Carter expressed his "profound sadness" at the death, he made no reference to terrorism.

BBC: Files show US-UK tensions over Northern Ireland in 1979

He might be suffering from profound sadness, depression, despair, self aggrandizement and narcissism.

CNN: How a boy becomes a killer

His 8-year-old daughter Enatnesh stands by the door way and takes this all in with a look of profound sadness.

NPR: Rural Ethiopia Ignores Law Against Child Brides