My father's death had a profound effect on us all.

父亲的去世深深地影响了我们全家。

《牛津词典》

So the spread of agriculture could very well have a profound effect on the composition of Earth's atmosphere.

所以农业的扩张很可能对地球大气的组成产生深远的影响。

youdao

It can have a profound effect on your brain, improving cognitive skills not related to language and even shielding against dementia in old age.

它可以对你的大脑产生深远的影响，提高与语言无关的认知能力，甚至预防老年痴呆。

youdao

Traversing the Bernese Oberland on a summer holiday had a profound effect on the 19-year-old author-to-be.

BBC: In Alpine villages, Hobbits lurk

Marian Mahoney, governor of HMP Moorland, said the riots had a "profound effect" on the prison.

BBC: Damage at prison

And this has a profound effect on the weather patterns and on the rainfall events.

NPR: Can Climate Change Explain Odd Weather?