Each specific promoter was used to treat specific type of targeting cancer cells in those treating protocols, while most tumor grows rapidly causing the nourishing vessel cannot supply all the tumor cells which prevents the effect of prodrugs.
上述治疗方案中,每一特异启动子仅能进行针对某一类型肿瘤细胞靶向基因治疗,而绝大多数恶性实体瘤的生物学特性为生长迅速,致使其滋养血管不能及时供应所有肿瘤细胞,该特点使前体药物难以接近所有肿瘤细胞。
参考来源 - 慢病毒介导的双自杀基因靶向治疗大肠癌的实验研究Bicyclic furo2,3-dpyrimidine nucleosides represent an entirely novel class of nucleoside prodrugs with unprecedented selectivity for varicella-zoster virus (VZV).
呋喃2,3-d嘧啶核苷是一类新型的、特异性治疗水痘带状疱疹病毒的核苷前药。
参考来源 - 呋喃[2·2,447,543篇论文数据，部分数据来源于NoteExpress
Bio-reductive drugs are pro-drugs that can selectively target the hypoxia cells in tumors. In reductive environment, they are reductively metabolized to generate toxic species.
生物还原剂是一种具有肿瘤乏氧靶向性的前药，它会在还原性环境中被还原产生具有细胞毒性的代谢物。
The "pro-life" argument regarding improvement in pain control through drugs, hospices etc. only covers those dying in pain.
那些“生命权”的辩论者注重通过药物和晚期病人护理机构等来改善痛苦的控制。 只能掩盖令人死亡的疼痛。
OBJECTIVE: to understand the trend of application of antiacids and other drugs for peptic ulcer, so as to pro-vide the information for rational clinical use of these kinds of drugs.
目的：了解抗酸药及治疗消化性溃疡病类药物的应用趋势，为临床合理用药提供参考。
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