First, keep focused on the overall interests while adhering to principles.

第一，要着眼大局，坚持原则。

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This lack of laws or first principles makes construction of software systems as much an art as a science.

这种缺少法则或者第一原则的事实使得软件系统更像是一门艺术而非科学。

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To understand the foundational capabilities of portfolio management, it is first necessary to understand the key principles or elements of this discipline.

要了解项目组合管理的基本能力，首先需要的是了解该规程的关键原则或元素。

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As Petraeus knows, one of the first principles of counter-insurgency doctrine is that any successful campaign must have a credible local partner.

NEWYORKER: General Principles

He points to one of the most time-tested principles in science: the first law of thermodynamics.

FORBES: Powered By Blarney?

His plan, said aides, was to relaunch his party, the Freedom People (PdL), on the basis of the free-market principles he espoused when he first entered office in 1994, but which he signally failed to apply in the nine subsequent years when he governed Italy.

ECONOMIST: Italian politics