Positive cardiac remodeling occurs after percutaneous closure of large atrial septal defect, irrespective of the magnitude and length of volume overload.

房间隔缺损封堵术后早期即出现心脏正向重构，且这些变化的程度和时间不受患者接受封堵时的年龄影响。

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But Chambers, banned in 2003 for a positive drug test, has expressed his determination for closure over his past and has looked determined to let his feet do the talking.

BBC: Chambers storms to gold in Turin

He said any school closure "created emotion", but the report offered a positive way to move forward in some areas, especially where a federal system would help keep the local school going.

BBC: NEWS | UK | Wales | North West Wales | 29 schools 'to close' in shake-up

London Olympic chief Lord Coe believes the closure of Don Valley Stadium should not be viewed as a blow to building a positive 2012 legacy.

BBC: Lord Coe