Setting up was a breeze -- no software was required on either our MacBook Pro or ThinkPad T410S. Of course, while the plug and play ability is nice, we did wish there was software for customizing the scroll wheel shortcuts (USB Overdrive let us do that with no issue on our Mac, however).
Its self-healing architecture, for example, and the ability to plug in and remove processors while the machine is running, would have obvious uses in e-commerce, where servers must be kept online around the clock and the amount of processing power needed may vary seasonally.