The answer is the "gold standard" double blind, placebo controlled study.

答案是“金标准”，双盲，安慰剂对照研究。

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So, in fact, this double blind placebo controlled study does not guarantee safety or efficacy because the test leaves far too many questions unanswered.

所以实际上，双盲对照研究并不会保证疗效和安全，因为它留下太多无法回答的问题。

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DESIGN: a randomized grouping comparison and placebo controlled study.

设计：随机对比观察，安慰剂对照。

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Packer says this is the first placebo-controlled study in acute heart failure to show a clinical benefit.

FORBES: Open Questions For Heart Failure Drugs

This study is actually the first of four placebo-controlled, Phase III trials to be completed.

FORBES: Pfizer And J&J Alzheimer's Drug Fails Late-Stage Trial

Claire Bombardier, the University of Toronto researcher who had conducted Merck's big ulcer study, criticized the new studies for not being placebo-controlled.

FORBES: Behind Merck's Fall