It has been demonstrated that TAK-147 is more potent and brain-specific AChE inhibition than tacrine and physostigmine, and has been approval potentiating choline acetyltransferase ( ChAT ) activity in cultured rat septal neurons more potent than donepezil, tacrine and revastigmine.
TAK-147与毒扁豆碱和他克林相比是具有更强作用和中枢选择性的胆碱酯酶抑制剂。 有报道表明,TAK-147对于培养的大鼠脊神经元具有比多奈派齐、他克林和 Revastigmine更强的提高ChAT活性的作用。
参考来源 - 乙酰胆碱脂酶抑制剂TAK·2,447,543篇论文数据,部分数据来源于NoteExpress
以上来源于: WordNet
N an alkaloid found in the Calabar bean used esp in eye drops to reduce pressure inside the eyeball. Formula: C15H21N3O2 毒扁豆碱 (Also called eserine)
Objective To compare the myotic effects of physostigmine, pilocarpine and neostigmine in rabbits.
目的比较新斯的明、毒扁豆碱和毛果芸香碱对兔眼的缩瞳作用。
These results suggested that the central depressant effect of anisodine can be antagonized by physostigmine and adrenomimetics, while regitine is synergistic.
结果提示樟柳碱的中枢抑制作用,不仅与其抗胆碱作用有关,还可能与其抗肾上腺素能作用有一定关系。
Conclusion Physostigmine, neostigmine and pilocarpine, when applied locally to the eye in rabbits, could cause myosis and their time-effect relationships were comparable.
论新斯的明、毒扁豆碱和毛果芸香碱滴眼给药,均能缩小兔眼瞳孔,其时效关系相似。
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