A new“Cocktail”has been established, including probes of phenacetin, tolbutamide, mephenytoin, dextromephen and midazolam. A LC-MS/MS analytical method has been established to determine the above 5 probes and their corresponding metabolites.
结果:本实验建立了全新“Cocktail”探针药物组合(非那西丁+甲苯磺丁脲+美芬妥英+右美沙芬+咪达唑仑),并建立了同时检测以上五种探针药物及其相应代谢产物的LC-MS/MS分析方法。
参考来源 - 痹祺胶囊组方配伍对细胞色素P450同工酶活性的影响The relative standard deviation for 5.0×10-6g/mL of phenacetin was 2.8% (n=7).
对5.0xl0一勺mL的非那西丁溶液进行7次平行的测定,相对标准偏差为2.8%。
参考来源 - 分子印迹—化学发光法在药物分析中的研究与应用·2,447,543篇论文数据,部分数据来源于NoteExpress
以上来源于: WordNet
N a white crystalline solid formerly used in medicine to relieve pain and fever. Because of its kidney toxicity it has been superseded by paracetamol. Formula: CH3CONHC6H4OC2H5 非那西丁 (Also called acetophenetidin)
The procedure was applied to the assay of aminopyrine-phenacetin composite tablets and satisfactory r…
本法用于去痛片的分析,得到了良好的回收率。
The present paper described an application of activated carbon to the phenacetin production in details.
详细介绍活性炭在非那西丁生产中的应用状况。
CONCLUSION liver cells were damaged severely in the rats with DEN induced hepatoma. The liver mass increased without any significant changes in the liver function tests as phenacetin metabolites.
结论在DEN诱发肝癌大鼠,肝细胞严重受损,肝脏体积增大,非那西丁代谢等肝功能试验无明显改变。
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