And while each new generation of skinny pills has so far proven more dangerous than effective-remember fen-phen and ephedra? -experts continue their search for a safe diet pill that works.

尽管至今为止，每一代减肥药都被证明其危险性比其效果大——还记得芬—芬和麻黄吗——但专家们还在继续研制“有效的”安全的减肥药。

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Unlike Xenical, previous diet drugs, such as Redux and Phenfluramine, best known as the "phen" in Fen-Phen, worked on the brain to control the body's feeling of "fullness".

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The long-running scandal over a fen-phen case gone awry has already destroyed the careers of at least three lawyers as well as the Kentucky judge who oversaw the original lawsuit.

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The closest thing to a real success, a two-drug combination known as fen-phen, helped people lose as much as 30 pounds a year by making them feel satiated, but it caused heart valve problems in some and pulmonary hypertension in others.

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