Immediately take the dog to the vet to avoid tissue loss and permanent damage.

立即带狗狗去看兽医避免纱布丢失和永久损伤。

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Strokes, which occur when blood flow to the brain is blocked, can kill brain tissue and are one of the worldwide leading causes of death and permanent disability.

发生在脑部血流阻断时的卒中可能杀伤脑组织，并且在世界范围内都是死亡和永久性致残的主要原因之一。

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Healthy tissue then grows on and around the material to create a permanent blockage.

健康的组织在这个物质内部及其周围成长，生成一个永久性的阻碍。

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In Peyronie's disease, problems in the normal wound-healing process result in permanent scar tissue.

CNN: Peyronie's disease

Severe frostbite however requires immediate medical attention, because it can cause permanent damage to skin underlying tissue, bones and muscle, and can lead to complications including infection, and nerve damage.

FORBES: Important Cold Weather Safety and Tips